Cholesterols and the Mixed Variety of the Gall Bladder Stones
These types of gall stones have already been described to be due to the high presence of the cholesterols and other mixtures in varying ratios.
The solubility of the cholesterol in the bile depends on the relative molar concentration and the relative ratios of the bile acids, lecithin, and of course cholesterols.
The fact that cholesterol is highly insoluble in the water is already known, and hence they are kept in a solution and this solution is given the name of mixed micelles which are the initiation factors in the absorptions of the molecules of fat in the process of fat absorption, with the prior help of the phospholipids and also bile salts.
The mechanism of the formation of the stones that is lithiogenic properties of the bile is the increase in the secretion of cholesterols in the bile. The main reasons that may be behind all this hyper secretory activity of the bile may be closely associated with the facts of high calorie diets, obesity, or many drugs having such effects and may also result from the activity of the hydroxymethylglutaryl coenzyme which is said to be a kind of a reductase, that is the rate limiting enzyme of the hepatic synthesis of the cholesterols.
Thus, in some cases where these ratios are disturbed by the conversion of the cholesterols to bile acids and also the decrease of the lithiogenic cholesterols, the cause of the bile being lithiogenic may also be the fact that there is a decrease in the secretions of the liver, or it may also be due to the impairments of the circulations which are said to be Enterohepatic circulations.
For the formations of the stones of the gall bladder the supersaturated bile in cholesterol requires both the processes of the nucleation as well as the cholesterol monohydrate crystal formations.